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核心代码：

function fnSuccMainBody(xhr){	// main body	document.getElementById("main").innerHTML = xhr.responseText;		// sub : sub body	if(document.getElementById("submain") != null)		ShowComments();}function fnSuccSubMainBody(xhr){	document.getElementById("submain").innerHTML = xhr.responseText;}function AjaxRequest(url, data, fnSucc){       	var xhr = window.XMLHttpRequest ? new XMLHttpRequest() : new ActiveXObject('Microsoft.XMLHTTP');        	xhr.onreadystatechange = function(){		AjaxCallBack(xhr, fnSucc);	};        	xhr.open("post", url, true);	xhr.setRequestHeader('Content-type', 'application/x-www-form-urlencoded;');	 	xhr.send(data);}function AjaxCallBack(xhr, fnSucc){	if(xhr.readyState == 4)	{		var s = xhr.status;		if(s >= 200 && s < 300)			fnSucc(xhr);		else			;	}	}// 调用function showMain(){	var url = xxx;	var data = xxx;	AjaxRequest(url, data, fnSuccMainBody);		}function showSubMain(){	var url = xxx;	var data = xxx;	AjaxRequest(url, data, fnSuccSubMainBody);			}

参考：

div+ajax实现类似iframe功能

http://lz12366.iteye.com/blog/1137458

frameset和div常规布局的优缺点比较

http://blog.csdn.net/zhangxinrun/article/details/5677829